Sensitivity analysis of effective transverse shear viscoelastic and diffusional properties of myelinated white matter

Motivated by the need to interpret the results from a combined use of in vivo brain Magnetic Resonance Elastography (MRE) and Diffusion Tensor Imaging (DTI), we developed a computational framework to study the sensitivity of single-frequency MRE and DTI metrics to white matter microstructure and cell-level mechanical and diffusional properties. White matter was modeled as a triphasic unidirectional composite, consisting of parallel cylindrical...