Retinal Nerve Fiber Layer Converges More Convexly on Normal Smaller Optic Nerve Head.

Published on Aug 1, 2015in Journal of Glaucoma2.503
· DOI :10.1097/IJG.0000000000000011
Kyoung In Jung13
Estimated H-index: 13
(Catholic University of Korea),
Jeong Ah Shin1
Estimated H-index: 1
+ 1 AuthorsChan Kee Park28
Estimated H-index: 28
PURPOSE: To investigate retinal nerve fiber layer (RNFL) configuration in the optic nerve head (ONH) and peripapillary area according to disc size and to determine whether it explains cup discrepancy among eyes with different disc sizes. METHODS: Horizontal and vertical RNFL curvature and mean thickness were measured using confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph) in 63 normal subjects grouped by disc size. Average and quadrant RNFL thickness, disc size, average cup-to-disc ratio (CDR), and convergence angle at the optic disc were also measured using Cirrus HD-optical coherence tomography. The relationships between disc size and RNFL curvature, thickness, angle at optic disc, and CDR were evaluated. RNFL curvature and convergence angle reflects convexity "on" and "into" the optic disc, respectively. RESULTS: CDR was smaller for small discs and was positively correlated with disc size (P<0.001). Horizontal and vertical RNFL curvatures were significantly more convex for small than large discs (P=0.001, 0.017). Horizontal and vertical RNFL angles at the optic disc were positively correlated with disc size (P<0.001, P=0.012). Optic disc area was negatively correlated with mean RNFL thickness at the optic disc margin measured by HRT (P=0.002), but not in the peripapillary area by optical coherence tomography. CONCLUSIONS: Using imaging techniques, we demonstrated that the shape of the RNFLs converging "on" and entering "into" the optic disc was more convex for small optic discs compared with large discs. A low CDR for small discs could be mediated by these RNFL profiles at the ONH, which may guide the clinical evaluation of glaucomatous ONH damage.
Cited By3
#1Yasushi Kitaoka (St. Marianna University School of Medicine)H-Index: 22
#2Masaki TanitoH-Index: 33
Last. Toru Nakazawa (Tohoku University)H-Index: 59
view all 7 authors...
Purpose. The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods. The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD)...
#1Khalil Ghasemi Falavarjani (IUMS: Iran University of Medical Sciences)H-Index: 29
#2Hamideh Shenazandi (IUMS: Iran University of Medical Sciences)H-Index: 4
Last. Alfredo A. Sadun (UCLA: University of California, Los Angeles)H-Index: 75
view all 7 authors...
Abstract Objective To compare optic disc microvasculature measurements to the disc morphometrics in normal eyes. Design Cross-sectional study. Participants Fifty-eight healthy subjects. Methods Enface 4.5x4.5 mm optical coherence tomography angiography images were obtained from the optic disc of healthy individuals. The radial peripapillary capillary (RPC) and the nerve head (NH) en face images were obtained. Also, spectral domain OCT measurements of the peripapillary nerve fibre layer (NFL) thi...
#4A. Anton (University Medical Center Freiburg)H-Index: 2
Hintergrund: Die Messung der Bruch-Membran-Offnungsflache (BMO) und der darauf bezogenen dunnsten Nervenfaserschichtdicke (BMO-MRW) mittels optischer Koharenztomografie (OCT) wird seit 2014 in der klinischen Routine angewendet. Vor der Messung muss die Hornhautbrechkraft (ublicherweise als Mittelwert beider Hornhautkrummungsradien) angegeben werden. Mit diesen Angaben werden die kornealen Verzerrungen der Messstrahlen kompensiert. Ziel dieser Studie war es, den Einfluss dieser kornealen Korrektu...
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