Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome

<b><i>Introduction:</i></b> Alström syndrome is a rare recessive genetic disease caused by mutations in <i>ALMS1</i>, which encodes a protein that is related to cilia function and intracellular endosome trafficking. The syndrome has been linked to impaired glucose metabolism and CKD. Polymorphisms in <i>Alms1</i> have likewise been linked to CKD, but little is known about the modification of the...