Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes

Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes – DNA REPAIR AND CANCER Genomic instability is an enabling trait for cancer development. The main factor determining genome instability is the alteration of the DNA damage response (DDR) [1]. DDR has a pivotal role in the protection of DNA from endogenous and environmental damage. DDR is composed of proteins sensing DNA damage, proteins...