An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway
Abstract
Tumor organoids recapitulate pathological properties and would serve as an excellent ex vivo model for drug discovery. Here, we performed an unbiased drug screening on drivers-defined tumor organoids from mouse endometrial cancer, the most prevalent gynecological malignancy in human, with a small molecule library targeting epigenetic factors. Among them, menin-MLL inhibitors MI-136 and MI-463 scored. The therapeutic capacity of MI-136 was...
Paper Details
Title
An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway
Published Date
Jul 7, 2020
Journal
Volume
28
Issue
1-2
Pages
112 - 125
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