Neuroscience

Receptor

Dendritic spine

Biology

Synapse

Hippocampal formation

Extracellular matrix

Immunology

Long-term potentiation

Inflammation

Hippocampus

Microglia

Cell biology

Synaptic plasticity

Neuroplasticity

Biochemistry

Cell

A form of experience-dependent neuron-microglial communication is mediated by IL-33, which promotes hippocampal dendritic spine formation, synapse plasticity, and ECM engulfment and is required for memory consolidation.

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity