ERBB2b mRNA isoform encodes a nuclear variant of the ERBB2 oncogene in breast cancer

The presence of nuclear ERBB2 receptor‐type tyrosine kinase is one of the causes of the resistance to membrane ERBB2‐targeted therapy in breast cancers. It has been previously reported that this nuclear location arises through at least two different mechanisms: proteolytic shedding of the extracellular domain of the full‐length receptor and translation of the messenger RNA (mRNA)‐encoding ERBB2 from internal initiation codons. Here, we report a...