The cellular heat shock response monitored by chemical exchange saturation transfer MRI
Abstract
CEST-MRI of the rNOE signal has been demonstrated in vitro to be closely linked to the protein conformational state. As the detectability of denaturation and aggregation processes on a physiologically relevant scale in living organisms has yet to be verified, the aim of this study was to perform heat-shock experiments with living cells to monitor the cellular heat-shock response of the rNOE CEST signal. Cancer cells (HepG2) were dynamically...
Paper Details
Title
The cellular heat shock response monitored by chemical exchange saturation transfer MRI
Published Date
Jul 6, 2020
Journal
Volume
10
Issue
1
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