Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

Published on Jul 3, 2020in RSC Advances3.119
· DOI :10.1039/D0RA03636F
Javier Aguila-Rosas1
Estimated H-index: 1
(UAM: Universidad Autónoma Metropolitana),
Tomás Quirino-Barreda1
Estimated H-index: 1
+ 3 AuthorsEnrique Lima23
Estimated H-index: 23
(UNAM: National Autonomous University of Mexico)
Sources
Abstract
Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine–MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.
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