Added prognostic value of longitudinal changes of angiogenic factors in early‐onset severe pre‐eclampsia: a prospective cohort study

Objective To assess in women with early‐onset severe pre‐eclampsia whether longitudinal changes in angiogenic factors improve the prediction of adverse outcome. Design Prospective cohort study. Setting Maternity units in two Spanish hospitals. Population Women with diagnosis of early‐onset severe pre‐eclampsia. Methods Levels of placental growth factor (PlGF), soluble fms‐like tyrosine kinase (sFlt‐) and sFlt‐1/PlGF ratio were measured at...