Clinical Applications of Skin Bank Bioproducts

Published on Jan 1, 2020
· DOI :10.1007/978-3-030-45351-0_42
Linda Tognetti10
Estimated H-index: 10
,
Ernesto DePiano1
Estimated H-index: 1
+ 10 AuthorsPietro Rubegni32
Estimated H-index: 32
(UNISI: University of Siena)
Source
Abstract
Although the main field of application of homologous skin grafts from donor skin is extensive burns, they can be successfully used in a variety of critical and/or hard-to-heal wounds. Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head and neck, oral cavity, lower legs) is particularly challenging and can often be delayed due to local and systemic factors (e.g., bacterial burden, infections, diabetic neuropathy, and pressure). In these cases, integrated medical-surgical approach based on the use of skin bank bioproducts, i.e., homologous skin and dermal grafts, should be considered. By acting as a physiological biological dressing and scaffold, these products add several advantages, such as pain control, protection of deep structures (e.g., tendons, bones, cartilage, and nerves), stimulation of a functional new dermis (rather than a scar) and of re-epithelization with a significant reduction in wound closure time.
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References19
Newest
#1Michael A. TowlerH-Index: 1
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Last. Calvin L. Williams (Center for Excellence in Education)H-Index: 1
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: Chronic venous leg ulcers are responsible for significant morbidity and health care costs worldwide. This pilot study evaluated the effectiveness 2 biologically active grafts, TheraSkin and Apligraf, in conjunction with compression therapy. The study, not industry-sponsored, was designed and conducted as a prospective, head-to-head, single-site, randomized clinical trial to assess differences in healing rates, adverse outcomes, and treatment costs. The healing rates were different but not stat...
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Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to repl...
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