Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells.

Volume: 10, Issue: 1, Pages: 10320
Published: Jun 25, 2020
Abstract
Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD-associated CFH risk variants, Y402H in particular, impair FH function leading to complement overactivation. Whether this alone suffices to trigger AMD pathogenesis remains unclear. In AMD, retinal homeostasis is compromised due to the dysfunction of retinal pigment epithelium (RPE)...
Paper Details
Title
Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells.
Published Date
Jun 25, 2020
Volume
10
Issue
1
Pages
10320
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