An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Jiahuai Han; Jianfeng Wu; John Silke

doi:https://doi.org/10.12688/f1000research.22092.1

doi.org/10.12688/f1000research.22092.1

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

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Volume: 9, Pages: 653 - 653

Published: Jun 29, 2020

Abstract

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli. This review provides a succinct summary of multiple aspects of the biology, role, and substrates of the mammalian family of p38 kinases. Since p38 activity is implicated in inflammatory and other diseases, we also discuss the clinical...

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Paper Details

Title

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

DOI

doi.org/10.12688/f1000research.22092.1

Published Date

Jun 29, 2020

Journal

F1000Research

Volume

9

Pages

653 - 653

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