Repeatability of measuring the vessel density in patients with retinal vein occlusion: An optical coherence tomography angiography study.

Published on Jun 25, 2020in PLOS ONE2.74
· DOI :10.1371/JOURNAL.PONE.0234933
Kyeung-Min Kim3
Estimated H-index: 3
(CNU: Chungnam National University),
Min-Woo Lee8
Estimated H-index: 8
(CNU: Chungnam National University)
+ 3 AuthorsJung Yeul Kim16
Estimated H-index: 16
(CNU: Chungnam National University)
PURPOSE To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO). DESIGN Prospective observational study. SUBJECTS Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study. METHODS Two consecutive 3×3 mm pattern scans were performed using the Cirrus HD-OCT 5000 along with AngioPlex software (Carl Zeiss Meditec) in each eye by single skilled examiner. All scans were analyzed using en face OCTA images to measure vessel density (VD) automatically. For further analysis of the effect of central macular thickness(CMT), eyes were divided into two groups according to CMT of 400μm (Group 1: CMT > 400μm, Group 2: CMT 400μm) were 0.348 and 22.55% respectively. In group 2 (CMT < 400μm), the ICC and CV of the full VD were 0.910 and 7.76%, respectively. CONCLUSIONS The repeatability of VD measurement in eyes with RVO was reasonably comparable to previous studies. Repeatability of VD measurement was significantly affected by central macular thickness.
📖 Papers frequently viewed together
25 Citations
100 Citations
Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) ...
5 CitationsSource
#1Min-Woo Lee (CNU: Chungnam National University)H-Index: 8
#2Kyeung-Min Kim (CNU: Chungnam National University)H-Index: 3
Last. Jung Yeul Kim (CNU: Chungnam National University)H-Index: 16
view all 5 authors...
Aim To analyse the repeatability of vessel density (VD) measurements using optical coherence tomography angiography (OCTA) in patients with retinal diseases. Methods Two consecutive VD measurements using OCTA were analysed prospectively in patients with retinal diseases (diabetic macular oedema (DME), retinal vein occlusion (RVO) with macular oedema, epiretinal membrane (ERM), wet age-related macular degeneration (AMD)). The intraclass correlation coefficient (ICC), coefficient of variation (CV)...
25 CitationsSource
#1Qian Wang (Capital Medical University)H-Index: 11
#2Szy Yann Chan (PKU: Peking University)H-Index: 7
Last. Wen Bin Wei (Capital Medical University)H-Index: 26
view all 7 authors...
Purpose To examine the vascular density in different retinal layers and in the choriocapillaris in eyes with retinal vein occlusions (RVO).
15 CitationsSource
#1Chung Yee Chung (HKU: University of Hong Kong)H-Index: 4
#1Chung Yee Chung (United Christian Hospital)H-Index: 1
Last. Kenneth K. W. Li (United Christian Hospital)H-Index: 18
view all 4 authors...
Purpose To compare the imaging of retinal vein occlusion (RVO) with optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) and evaluate their roles in clinical management.
16 CitationsSource
#1Yuanjun Zhao (Penn State Milton S. Hershey Medical Center)H-Index: 5
#2Sarah R. Weber (UM: University of Michigan)H-Index: 6
Last. Jeffrey M. Sundstrom (UM: University of Michigan)H-Index: 14
view all 11 authors...
Purpose: To investigate the molecular components of the vitreous in order to better understand retinal physiology and disease. Methods: Vitreous was acquired from patients undergoing vitrectomy for macular hole and/or epiretinal membrane, postmortem donors, and C57BL/6J mice. Unbiased proteomic analysis was performed via electrospray ionization tandem mass spectrometry (MS/MS). Gene ontology analysis was performed and results were confirmed with transmission electron microscopy, atomic force mic...
35 CitationsSource
#1Federico Corvi (University of Milan)H-Index: 13
#2Marco Pellegrini (University of Milan)H-Index: 15
Last. Andrea Giani (University of Milan)H-Index: 17
view all 6 authors...
Purpose To evaluate the reproducibility of parafoveal microvascular anatomy of 7 different optical coherence tomography angiography (OCT-A) devices by comparing vessel density (VD), fractal dimension (FD), and foveal avascular zone (FAZ) of superficial and deep capillary plexus in healthy volunteers. Design Reliability analysis. Methods Consecutive healthy volunteers presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan in the sam...
100 CitationsSource
#1Fred K. Chen (UWA: University of Western Australia)H-Index: 29
#2Moreno Menghini (UWA: University of Western Australia)H-Index: 10
Last. Danuta M. Sampson (UWA: University of Western Australia)H-Index: 4
view all 6 authors...
Purpose: To measure intrasession repeatability and interocular symmetry of the foveal avascular zone area (FAZA) and superficial retinal vessel density (SRVD) using AngioVue Analytics optical coherence tomography angiography (OCTA). Methods: Fifty healthy individuals were prospectively enrolled. OCTA scans (3 × 3 and 6 × 6 mm) were acquired twice in right and once in left eyes. FAZA (with and without rescaling) and SRVD for 18 regions (whole, fovea, parafovea, six parafoveal subregions, and nine...
20 CitationsSource
#1Mayss Al-Sheikh (UCLA: University of California, Los Angeles)H-Index: 17
#2Tudor TepelusH-Index: 12
Last. Srinivas R. Sadda (UCLA: University of California, Los Angeles)H-Index: 79
view all 4 authors...
Aims To determine the repeatability of optical coherence tomography angiography (OCT-A)-derived automated vessel density measurements in the superficial retinal layer (SRL) and deep retinal layer (DRL) in healthy individuals. Methods 41 eyes of 21 healthy individuals were included in this study. OCT-A was performed using the NIDEK RS-3000 Advance with prototype OCT-A software. Each subject underwent two scanning sessions with 5–10 min in between. En face images of the retinal vasculature were ge...
94 CitationsSource
#1Jiaxian GuoH-Index: 2
#2Xiangjun SheH-Index: 2
Last. Xiaodong SunH-Index: 17
view all 4 authors...
Purpose: The aim of this study was to evaluate the repeatability and reproducibility of foveal avascular zone (FAZ) area measurements using AngioPlex spectral domain optical coherence tomography (OCT) angiography in normal subjects. Methods: Twenty-two healthy subjects (25 eyes) underwent FAZ area measurements with AngioPlex OCT. Each volunteer was separately examined 3 consecutive times by the 2 experienced observers. The FAZ area was measured using ImageJ software. Intraobserver repeatability ...
33 CitationsSource
#1Il-Hwan Shin (CNU: Chungnam National University)H-Index: 2
#2Woo-Hyuk Lee (CNU: Chungnam National University)H-Index: 5
Last. Jung Yeul Kim (CNU: Chungnam National University)H-Index: 16
view all 5 authors...
PURPOSE: To determine the repeatability of measuring the thickness of the central macula, retinal nerve fiber layer, and ganglion cell-inner plexiform layer (GC-IPL) using spectral domain optical coherence tomography (Cirrus HD-OCT) in eyes with age-related macular degeneration. METHODS: One hundred and thirty-four eyes were included. The measurement repeatability was assessed by an experienced examiner who performed two consecutive measurements using a 512 × 128 macular cube scan and a 200 × 20...
12 CitationsSource
Cited By3
#1Qian Wang (Capital Medical University)H-Index: 11
#2Lili Liu (PKU: Peking University)H-Index: 1
Last. Ya Xing Wang (Capital Medical University)H-Index: 31
view all 14 authors...
Background Diabetic retinopathy and chronic kidney disease are both major complications of diabetes mellitus. We explored the relationship between retinal vessel density (VD) and albuminuria in diabetic patients without conventionally defined diabetic retinopathy. Methods The cross-sectional community-based Kailuan Diabetic Retinopathy Study included patients with type 2 diabetes without diabetic retinopathy who participated in the community-based longitudinal Kailuan study and who had undergone...
Purpose To analyze the repeatability of vessel density (VD) measurements and manual foveal avascular zone (FAZ) measurements using optical coherence tomography angiography (OCTA) in patients with retinal vein occlusion (RVO) without macular edema. Methods The study population consisted of patients with RVO and central macular thickness l300 μm. For each subject, measurements were performed twice with a 5-minute interval. The intraclass correlation coefficient (ICC) and coefficient of variation (...
#1Lekha Mukkamala (UC Davis: University of California, Davis)H-Index: 1
Last. Susanna S. ParkH-Index: 6
view all 4 authors...
Purpose Although commercial optical coherence tomography angiography (OCTA) machines quantitate retinal vascular density (VD) by dividing the vasculature into superficial and deep capillary plexus (SCP, DCP), histology reveals three distinct plexus layers. This study tested the hypothesis that the VD measurement of three distinct retinal plexus layers obtained using custom segmentation has high repeatability comparable to that of automatically segmented SCP and DCP layers. Materials and methods ...