Repeatability of measuring the vessel density in patients with retinal vein occlusion: An optical coherence tomography angiography study.

Published on Jun 25, 2020in PLOS ONE2.74
· DOI :10.1371/JOURNAL.PONE.0234933
Kyeung-Min Kim3
Estimated H-index: 3
(CNU: Chungnam National University),
Min-Woo Lee8
Estimated H-index: 8
(CNU: Chungnam National University)
+ 3 AuthorsJung Yeul Kim16
Estimated H-index: 16
(CNU: Chungnam National University)
Sources
Abstract
PURPOSE To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO). DESIGN Prospective observational study. SUBJECTS Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study. METHODS Two consecutive 3×3 mm pattern scans were performed using the Cirrus HD-OCT 5000 along with AngioPlex software (Carl Zeiss Meditec) in each eye by single skilled examiner. All scans were analyzed using en face OCTA images to measure vessel density (VD) automatically. For further analysis of the effect of central macular thickness(CMT), eyes were divided into two groups according to CMT of 400μm (Group 1: CMT > 400μm, Group 2: CMT 400μm) were 0.348 and 22.55% respectively. In group 2 (CMT < 400μm), the ICC and CV of the full VD were 0.910 and 7.76%, respectively. CONCLUSIONS The repeatability of VD measurement in eyes with RVO was reasonably comparable to previous studies. Repeatability of VD measurement was significantly affected by central macular thickness.
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