Immediate Infusion Reaction to Intravenous Ustekinumab in Three Crohn's Disease Patients: A Case Report and Review of the Literature.

Published on Jan 13, 2021in Journal of Crohn's and Colitis8.658
· DOI :10.1093/ECCO-JCC/JJAA115
Pepijn W. A. Thomas1
Estimated H-index: 1
(Radboud University Nijmegen),
Gerben Ferwerda30
Estimated H-index: 30
+ 1 AuthorsFrank Hoentjen16
Estimated H-index: 16
(Radboud University Nijmegen)
Recently, ustekinumab has been approved for the treatment of Crohn's disease and ulcerative colitis. Treatment is started with an intravenous induction dose, followed by a subcutaneous dosage. We present three patients with therapy-refractory Crohn's disease, who experienced an immediate infusion reaction to intravenous administration of ustekinumab. In two of these patients a subsequent reaction to subcutaneous injections occurred. Clinical features and pathophysiology are discussed.
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