Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib
Abstract
Iron plays a major role in multiple processes involved in cell homeostasis such as metabolism, respiration and DNA synthesis. Cancer cells exhibit pronounced iron retention as compared to healthy counterpart. This phenomenon also occurs in multiple myeloma (MM), a hematological malignancy characterized by terminally differentiated plasma cells (PCs), in which serum ferritin levels have been reported as a negative prognostic marker. The aim of...
Paper Details
Title
Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib
Published Date
Sep 1, 2020
Journal
Volume
36
Pages
101611 - 101611
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