Improved radiosynthesis of 123I-MAPi, an auger theranostic agent

Volume: 99, Issue: 1, Pages: 70 - 76
Published: Jul 2, 2020
Abstract
Purpose 123I-MAPi, a novel PARP1-targeted Auger radiotherapeutic has shown promising results in pre-clinical glioma model. Currently, 123I-MAPi is synthesized using multistep synthesis that results in modest yields and low molar activities (MA) that limits the ability to translate this technology for human studies where high doses are administered. Therefore, new methods are needed to synthesize 123I-MAPi in high activity yields (AY) and...
Paper Details
Title
Improved radiosynthesis of 123I-MAPi, an auger theranostic agent
Published Date
Jul 2, 2020
Volume
99
Issue
1
Pages
70 - 76
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