Repair of osteochondral defect using icariin-conditioned serum combined with chitosan in rabbit knees

Osteochondral defects caused by an acute traumatic injury or articular degeneration remains difficult to be manipulated. Repair of articular defects is still a great challenge for both tissue engineers and orthopedic surgeons. Therefore, combination of biomaterials with cartilage promotive drugs is well worth being developed to support the regeneration of both cartilage and subchondral bone.Rabbits undergoing osteochondral defect surgery were...