Bile reflux in patients with nerd is associated with more severe heartburn and lower values of mean nocturnal baseline impedance and chemical clearance

Background Mean nocturnal baseline impedance (MNBI) and postreflux swallow‐induced peristaltic wave (PSPW) index are novel impedance‐based markers of reflux, but the effect of bile reflux on these metrics is unknown. The aim of this study was to evaluate bile reflux, MNBI, and PSPW index in patients with endoscopy‐negative GERD partially responsive to PPI therapy. Methods All patients underwent off‐PPI endoscopy, esophageal manometry,...