Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia.
Abstract
Autologous T cells engineered to express a chimeric antigen receptor (CAR) against the CD19 antigen are in the frontline of contemporary hemato-oncology therapies, leading to high remission rates in B-cell malignancies. Although effective, major obstacles involve the complex and costly individualized manufacturing process, and CD19 target antigen loss or modulation leading to resistant and relapse following CAR therapy. A potential solution for...
Paper Details
Title
Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia.
Published Date
Jul 2, 2020
Journal
Volume
11
Pages
1347
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Notes
History