Review paper

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Volume: 41, Issue: 8, Pages: 531 - 543
Published: Aug 1, 2020
Abstract
Recent advances in the pathophysiologic understanding of COVID-19 infection have suggested a critical role of cytokine release syndrome (CRS) in severe COVID-19 patients.Several inflammatory cytokines that are involved in CRS and correlate with adverse clinical outcomes in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs).JAK-STAT signaling may be an excellent therapeutic target for the development of...
Paper Details
Title
Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19
Published Date
Aug 1, 2020
Volume
41
Issue
8
Pages
531 - 543
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