Perineural invasion in oral squamous cell carcinoma: Incidence, prognostic impact and molecular insight

Published on Nov 1, 2020in Journal of Oral Pathology & Medicine2.495
· DOI :10.1111/JOP.13069
Huda Alkhadar2
Estimated H-index: 2
(Dund.: University of Dundee),
Michaelina Macluskey14
Estimated H-index: 14
(Dund.: University of Dundee)
+ 1 AuthorsIan R. Ellis19
Estimated H-index: 19
(Dund.: University of Dundee)
BACKGROUND The objective of this study was to characterize the incidence and prognostic correlation of perineural invasion in oral squamous cell carcinoma and determine whether nerve growth factor and its receptor tyrosine Kinase A expression could be used as biological markers for perineural invasion. METHODS A retrospective review of pathology reports of 430 patients with oral squamous cell carcinoma who were treated from 1992 to 2014 in Tayside, Scotland was carried out. The expression of nerve growth factor and tyrosine Kinase A was assessed with immunohistochemistry in 132 tissue sections of oral squamous cell carcinoma. RESULTS Perineural invasion was identified in 17.4% of oral squamous cell carcinomas. High expression of nerve growth factor and tyrosine Kinase A was seen in 84% and 92% of oral squamous cell carcinoma respectively. Tumours with perineural invasion expressed nerve growth factor and tyrosine Kinase A with a greater frequency than tumours without perineural invasion. Perineural invasion and high expression of nerve growth factor were significantly associated with pain. Perineural invasion was significantly associated with stage IV tumours and poor disease-specific survival. CONCLUSIONS A higher level of expression of nerve growth factor and tyrosine Kinase A may predict perineural invasion and therefore may be considered as biological markers for perineural invasion in oral squamous cell carcinoma. Perineural invasion and nerve growth factor overexpression may contribute to the pain generation in oral cancer patients. Perineural invasion and nerve growth factor expression can predict the aggressiveness and prognosis of oral squamous cell carcinoma patients.
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