Nanotechnology

Organic chemistry

Aspergillus niger

Bacteria

Biology

Nuclear chemistry

Dynamic light scattering

Engineering

Nanoparticle

Fourier transform infrared spectroscopy

Aqueous solution

Chemistry

Metallurgy

Materials science

Antibacterial activity

Cadmium chloride

Chemical engineering

Genetics

Cadmium

Biochemistry

Advances in Polymer Technology

Cadmium-tolerant (6 mM) Aspergillus niger (RCMB 002002) biomass was challenged with aqueous cadmium chloride (1 mM) followed by sodium sulfide (9 mM) at 37°C for 96 h under shaking conditions (200 rpm), resulting in the formation of highly stable polydispersed cadmium sulfide nanoparticles (CdSNPs). Scanning electron microscopy revealed the presence of spherical particles measuring approximately 5 nm. A light scattering detector (LSD) showed that 100% of the CSNPs measure from 2.7 to 7.5 nm. Structural analyses by both powder X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) confirmed the presence of cubic CdS nanoparticles (CdSNPs) capped with fungal proteins. These CdSNPs showed emission spectra with a broad fluorescence peak at 420 nm and UV absorption onset at 430 nm that shifted to 445 nm after three months of incubation. The CdSNPs showed antimicrobial activity against E. coli , Pseudomonas vulgaris , Staphylococcus aureus , and Bacillus subtilis , and no antimicrobial activity was detected against Candida albicans . The biosynthesized CdSNPs have cytotoxic activity, with 50% inhibitory concentrations (IC50) of 190 μ g mL -1 against MCF7, 246 μ g mL -1 against PC3, and 149 μ g mL -1 against A549 cell lines.

Anticancer and Antibacterial Activity of Cadmium Sulfide Nanoparticles by<i>Aspergillus niger</i>

Anticancer and Antibacterial Activity of Cadmium Sulfide Nanoparticles byAspergillus niger