Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22–producing skin T-cell overactivation

Skin inflammatory symptoms of psoriasis are predominantly caused by pathogenic cytokines such as IL-17A/IL-22 that are overproduced by dysregulated T cells. Targeting pathogenic cytokines is effective in treatment of the symptoms but does not treat the T-cell dysregulation. The molecular mechanisms responsible for the T-cell dysregulation are currently poorly understood. We report here that psoriasis-associated suppression of CCL27/CCR10-derived...