Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism

In the arcuate nucleus of the hypothalamus reside two neuronal systems in charge of regulating feeding control and reproductive development. The melanocortin system responds to metabolic fluctuations adjusting food intake, whereas kisspeptin neurons are in charge of the excitatory control of gonadotropin hormone–releasing hormone (GnRH) neurons. While it is known that the melanocortin system regulates GnRH neuronal activity, it was recently...