Normal tissue complication probability of vertebral compression fracture after stereotactic body radiotherapy for de novo spine metastasis

Objective Stereotactic body radiotherapy (SBRT) for spine metastases is associated with post-treatment vertebral compression fracture (VCF). The purpose of this study is to identify clinical and radiation planning characteristics that predict post-SBRT VCF through a novel normal tissue complication probability (NTCP) analysis. Methods Patients with de novo spine metastases treated with SBRT between 2009 and 2018 at a single institution were...