Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model
Abstract
High grade serous ovarian cancer (HGSC) is the most common and deadly type of ovarian cancer, largely due to difficulties in early diagnosis and rapid metastasis throughout the peritoneal cavity. Previous studies have shown that expression of Notch3 correlates with worse prognosis and increased tumorigenic cell behaviors in HGSC. We investigated the mechanistic role of Notch3 in a model of metastatic ovarian cancer using the murine ovarian...
Paper Details
Title
Notch3 signaling promotes tumor cell adhesion and progression in a murine epithelial ovarian cancer model
Published Date
Jun 11, 2020
Journal
Volume
15
Issue
6
Pages
e0233962 - e0233962
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