Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice
Abstract
Tissue regeneration capacity declines with aging in association with heightened oxidative stress. Expression of the oxidant-generating enzyme, NADPH oxidase 4 (Nox4), is elevated in aged mice with diminished capacity for fibrosis resolution. Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal (BET) family of proteins that function as epigenetic “readers” of acetylated lysine groups on histones. In this study,...
Paper Details
Title
Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice
Published Date
Jul 23, 2020
Journal
Volume
5
Issue
14
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