Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites
Abstract
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative to other cytochrome b inhibitors, JAG21 has improved solubility and ADMET properties, without need for pro-drug. JAG21 significantly reduces Toxoplasma gondii...
Paper Details
Title
Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites
Published Date
Jun 9, 2020
Volume
10
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