Pure red cell aplasia and seronegative myasthenia gravis in association with thymoma.

Published on Jun 14, 2020in Journal of Community Hospital Internal Medicine Perspectives
· DOI :10.1080/20009666.2020.1770019
Sun Yong Lee1
Estimated H-index: 1
(San Joaquin General Hospital),
Amandeep Singh Gill2
Estimated H-index: 2
(San Joaquin General Hospital),
Syung Min Jung1
Estimated H-index: 1
(San Joaquin General Hospital)
Sources
Abstract
Pure red cell aplasia is an uncommon paraneoplastic syndrome of thymoma. Myasthenia gravis is the most common paraneoplastic syndrome associated with thymoma. We present a case of a 79-year-old Pac...
📖 Papers frequently viewed together
References7
Newest
#1Satoru Moriyama (Nagoya City University)H-Index: 23
#2Motoki Yano (Aichi Medical University)H-Index: 3
Last. Ryoichi Nakanishi (Nagoya City University)H-Index: 9
view all 9 authors...
Background: Pure red cell aplasia (PRCA) associated with thymoma is relatively rare, and relevant reports are limited. We investigated the clinical features and outcomes of PRCA associated with thymoma in this study. Methods: A retrospective review of all PRCA patients who underwent surgical resection of thymoma from April 1, 2004, to December 31, 2015, was performed. Results: We experienced eight patients with PRCA among 146 patients who underwent surgical resection of thymoma. Extended thymect...
5 CitationsSource
#1Doron Feinsilber (MCW: Medical College of Wisconsin)H-Index: 3
#2Katrina A MearsH-Index: 6
Last. Brian L PettifordH-Index: 1
view all 3 authors...
: Thymomas are relatively uncommon malignancies of the anterior mediastinum and present with four distinct histological types based on the specific epithelial to lymphocyte ratio: spindle cell, epithelial predominant, lymphocyte predominant, or mixed. Each histologic type of thymoma has a propensity for local invasion and metastasis and can have a wide variety of paraneoplastic manifestations, myasthenia being the most common. We present a unique case of a 34-year-old African-American female who...
2 CitationsSource
#1Serena Macrì (University of Eastern Piedmont)H-Index: 1
#2Elisa Pavesi (University of Eastern Piedmont)H-Index: 7
Last. Irma Dianzani (University of Eastern Piedmont)H-Index: 26
view all 12 authors...
Diamond-Blackfan Anaemia (DBA) is a rare inherited anaemia caused by heterozygous mutations in one of 13 ribosomal protein genes. Erythroid progenitors (BFU-E and CFU-E) in bone marrow (BM) show a proapoptotic phenotype. Suspicion of DBA is reached after exclusion of other forms of BM failure syndromes. To improve DBA diagnosis, which is confirmed by mutation analysis, we tested a new approach based on the study of extracellular vesicles (EVs) isolated from plasma by differential centrifugations...
5 CitationsSource
#1Makoto Hirokawa (Akita University)H-Index: 30
#2Kenichi Sawada (Akita University)H-Index: 36
Last. Keiya Ozawa (Jichi Medical University)H-Index: 73
view all 11 authors...
Background Thymoma-associated pure red cell aplasia (PRCA) accounts for a significant proportion of cases of secondary PRCA and immunosuppressive therapy has been reported to be useful in this condition. However, because of its rarity, the long-term response and relapse rates after immunosuppressive therapy are largely unknown, and optimal management of this disorder remains unclear. The aim of this study was to collect more information on the outcome of patients with thymoma-associated PRCA. De...
86 CitationsSource
Summary Acquired pure red cell aplasia (PRCA) is a rare disorder of erythropoiesis that can develop in association with a thymoma. Optimal management of this subgroup is unclear, and there have been few series reporting long-term clinical outcomes. Here, we report features of 13 patients treated for PRCA associated with thymoma over 50 years at our institution. Surgical resection of the thymoma was insufficient for normalisation of erythropoiesis in all cases. T-cell gene rearrangement studies d...
94 CitationsSource
#1Martha Q. Lacy (Mayo Clinic)H-Index: 105
#2Paul J. Kurtin (Mayo Clinic)H-Index: 80
Last. Ayalew Tefferi (Mayo Clinic)H-Index: 150
view all 3 authors...
From 1980 through 1994, we identified 47 adult patients with acquired pure red cell aplasia (median age, 64 years; range, 22 to 84 years). Associated clinical disorders included T-cell large granular lymphocytic (LGL) leukemia, thymoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. Review of bone marrow findings in 40 patients showed absence of erythroid precursors in 14 patients and rare pronormoblasts in 26. None had morphologic evidence of myelodysplasia. T-cell receptor gene rear...
86 CitationsSource
Cited By0
Newest