Promising abscopal effect of combination therapy with thermal tumour ablation and intratumoural OK-432 injection in the rat osteosarcoma model

Tadashi Iwai; Naoto Oebisu; Manabu Hoshi; Kumi Orita; Akira Yamamoto; Shinichi Hamamoto; Ken Kageyama; Hiroaki Nakamura

doi:https://doi.org/10.1038/s41598-020-66934-6

doi.org/10.1038/s41598-020-66934-6

Promising abscopal effect of combination therapy with thermal tumour ablation and intratumoural OK-432 injection in the rat osteosarcoma model

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..., Hiroaki Nakamura

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Scientific Reports4.60

Volume: 10, Issue: 1

Published: Jun 15, 2020

Abstract

Treatment options for metastatic osteosarcoma are limited. The present study aimed to evaluate whether radiofrequency ablation (RFA) combined with intratumoural OK-432 injection induces systemic anti-tumour immunity in rat osteosarcoma model. Eighty of 145 rats were assigned to four groups to evaluate overall survival and tumour size: control (no treatment), RFA-only, OK-432, and RFA-OK-432. The remaining 65 were assigned for histological...

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Paper Details

Title

Promising abscopal effect of combination therapy with thermal tumour ablation and intratumoural OK-432 injection in the rat osteosarcoma model

DOI

doi.org/10.1038/s41598-020-66934-6

Published Date

Jun 15, 2020

Journal

Scientific Reports

Volume

10

Issue

1

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