Synthesis and characterization of novel naphthalene-derivatized tridentate ligands and their net neutral rhenium tricarbonyl complexes and cytotoxic effects on non-small cell lung cancer cells of interest

Rhenium complexes have possible fluorescence imaging, radioimaging and therapeutic applications and can also serve as a model system for 99mTc. The quest for new pharmaceutical agents is thus an expanding area of research. In this study, we report two net neutral complexes, [Re(CO)3(N(SO2)(1-nap)dien)] and [Re(CO)3(N(SO2)(2-nap)dien)], synthesized by treating fac-[Re(CO)3(H2O)3]+ with two novel tridentate ligands, (N(SO2)(1-nap)dienH and...