Enantioselective Copper-Catalyzed Alkynylation of Benzylic C–H Bonds via Radical Relay

The first enantioselective alkynylation of benzylic C–H bonds via copper-catalyzed radical relay has been established herein, which provides an easy access to structurally diverse benzylic alkynes in good yields with excellent enantioselectivities. A key step for the asymmetric copper-catalyzed radical relay process is the enantioselective capture of a benzylic radical with chiral (Box)CuII-alkynyl species. In addition, the reaction displays...