P1600KIDNEY PERFUSION WITH MESENCHYMAL STROMAL CELLS OR EXTRACELLULAR VESICLES PREVENTS ISCHAEMIC DAMAGE THROUGH CD73/ADO SYSTEM IN A RAT MODEL OF DCD DONATION

Background and Aims Adenosine (Ado), the main substrate of ATP, is a potent endogenous anti-inflammatory nucleoside. Hypoxia induces ATP depletion, AMP extracellular increase that is phosphohydrolyzed to ADO by the enzyme ecto-5′-nucleotidase (CD73). Constitutive CD73 expression is higher in deep cortex outer medulla that is the most vulnerable region to ischemic injury. Notably CD73 is also expressed on Mesenchymal Stromal Cell (MSC) and is...