Immunological Role of IgG Subclasses
Abstract
The loss of tolerance to self-antigens is the unequivocal “red line” of autoimmunity: both development of autoreactive T and B cells and production of polyclonal autoantibodies represent seminal keys to the pathogenesis of protean autoimmune diseases. Most of these autoantibodies are immunoglobulins G (IgG), functionally distinguished in four subclasses named IgG1, IgG2, IgG3, and IgG4, due to structural differences in the hinge and heavy chain...
Paper Details
Title
Immunological Role of IgG Subclasses
Published Date
Jun 11, 2020
Journal
Volume
50
Issue
4
Pages
427 - 444
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History