DNA Damage Repair Deficiency in Prostate Cancer

A significant proportion of prostate cancers harbor DNA damage repair (DDR) deficiency. These are particularly encountered in aggressive high-grade carcinoma and advanced metastatic disease. AR pathway signaling is frequently perturbed in prostate cancer and interacts with DDR pathway utilization. Functional defects in DDR pathways can sensitize tumors to genotoxic treatments, such as radiotherapy or chemotherapy. Molecular targeting of back-up...