Antithyroid drugs in Graves’ hyperthyroidism: differences between “block and replace” and “titration” regimes in frequency of euthyroidism and Graves’ orbitopathy during treatment

Whereas antithyroid drugs (ATD) are the preferred treatment modality for Graves’ hyperthyroidism (GH), there is still controversy about the optimal regimen for delivering ATD. To evaluate whether ‘Block and Replace’ (B + R) and ‘Titration’ (T) regimes are equivalent in terms of frequency of euthyroidism and Graves’ Orbitopathy (GO) during ATD therapy. A prospective multicentre observational cohort study of 344 patients with GH but no GO at...