Clinical history and management of bicuspid aortic valve in children and adolescents.

Published on Jun 1, 2020in Progress in Cardiovascular Diseases6.763
· DOI :10.1016/J.PCAD.2020.05.012
Talha Niaz8
Estimated H-index: 8
(Mayo Clinic),
Susan M. Fernandes33
Estimated H-index: 33
(Stanford University)
+ 2 AuthorsDonald J. Hagler88
Estimated H-index: 88
(Mayo Clinic)
Abstract Bicuspid aortic valve (BAV) is one of the most common congenital heart defects in children, adolescents and adults. BAV can occur as an isolated lesion or in association with other congenital heart defects, such as coarctation of the aorta or genetic syndromes like Turner syndrome. Although the majority of long term complications associated with BAV manifest later in life, children and adolescents may present with early onset valvular dysfunction or dilation of the aorta. BAV is a heterogeneous disease with a wide array of presentations at various ages, depending on the degree of aortic valve dysfunction, aortic dilation and presence of associated lesions. Aortic valve stenosis and/or regurgitation are the primary indications for intervention in children and adolescents with BAV. Although a majority of young patients with BAV also have some aortic dilation, interventions on the aorta are very rare during this time frame. Children and adolescents with BAV benefit from comprehensive assessment of their risk profile to determine follow-up surveillance intervals, sports recommendations, and timing of surgical intervention. The morphologic phenotype of BAV is important to identify, as it may predict future complications and prognosis.
#1Samuel Blais (Centre Hospitalier Universitaire de Sherbrooke)H-Index: 4
Last. N. Dahdah (Centre Hospitalier Universitaire Sainte-Justine)H-Index: 4
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BACKGROUND: Patients with bicuspid aortic valve (BAV) have a higher risk of developing aortic valve dysfunction and progressive proximal aorta dilatation, which can lead to aortic dissection. To this day, identification of children at risk of developing severe aortic dilatation during their pediatric follow-up is still challenging because most studies were restricted to adult subjects. The overarching goal of this study was to identify risk factors of aortic dilatation in children with BAV. METH...
4 CitationsSource
#1Michael Grattan (UWO: University of Western Ontario)H-Index: 5
#2Andrea Prince (Centre Hospitalier Universitaire Sainte-Justine)H-Index: 1
Last. Luc Mertens (U of T: University of Toronto)H-Index: 68
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BACKGROUND: Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect affecting 1% to 2% of the population. It is associated with ascending aorta dilatation. Valve morphology, aortic stenosis (AS), and aortic insufficiency (AI) have been proposed as potential risk factors; however, evaluating their role is difficult, as these factors are inherently related. The aim of this study was to determine whether BAV morphology and dysfunction are independent determinants for ascending aor...
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#1Kristina K. Rauser-Foltz (UNMC: University of Nebraska Medical Center)H-Index: 1
#2Lois J. Starr (UNMC: University of Nebraska Medical Center)H-Index: 6
Last. Anji T. Yetman (UNMC: University of Nebraska Medical Center)H-Index: 11
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#1Arif Hussain (Dal: Dalhousie University)H-Index: 9
#1Arif Hussain (Dal: Dalhousie University)H-Index: 2
Last. Santokh Dhillon (Dal: Dalhousie University)H-Index: 2
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Glenn N. Levine, MD, FACC, FAHA, Chair Patrick T. O’Gara, MD, MACC, FAHA, Chair-Elect Jonathan L. Halperin, MD, FACC, FAHA, Immediate Past Chair Nancy M. Albert, PhD, RN, FAHA[§§][1] Sana M. Al-Khatib, MD, MHS, FACC, FAHA Joshua A. Beckman, MD, MS, FAHA Kim K. Birtcher, PharmD, MS,
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Last. Maurice Enriquez-Sarano (Mayo Clinic)H-Index: 106
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Girls and women with Turner syndrome face a lifelong struggle with both congenital heart disease and acquired cardiovascular conditions. Bicuspid aortic valve is common, and many have left-sided he...
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#2Arístides de Alarcón (University of Seville)H-Index: 20
Last. Juan Carlos Segura LuqueH-Index: 2
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#1Sarah S. Pickard (Harvard University)H-Index: 6
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#1Shigeyuki Ozaki (Toho University)H-Index: 13
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Cited By1
#1Ahmet Sert (Selçuk University)H-Index: 12