Optimal Use of FOLFOXIRI Plus Bevacizumab as First-Line Systemic Treatment in Metastatic Colorectal Cancer

Colorectal cancer is the second leading cause of cancer-related deaths in the USA with more than half of diagnosed patients developing metastatic disease. The mainstay of treatment for metastatic disease is chemotherapy, and upfront treatment has generally consisted of a two-drug chemotherapy combination (FOLFOX or FOLFIRI) plus a biologic agent. In this review, we explore the emerging role of the three-drug chemotherapy combination FOLFOXIRI...