Effect of betulin and betulonic acid on isolated rat liver mitochondria and liposomes

Volume: 1862, Issue: 10, Pages: 183383 - 183383
Published: Oct 1, 2020
Abstract
The paper considers the effects of plant triterpenoid betulin and its derivative betulonic acid on rat liver mitochondria and liposomes. It was found that betulonic acid and, to a lesser extent, betulin, activate mitochondrial respiration in states 2 and 4 and inhibit ADP- and DNP-stimulated (uncoupled) respiration. The effect of betulonic acid resulted in a significant decrease of the respiratory control and ADP/O ratios and decrease in Δψ. The...
Paper Details
Title
Effect of betulin and betulonic acid on isolated rat liver mitochondria and liposomes
Published Date
Oct 1, 2020
Volume
1862
Issue
10
Pages
183383 - 183383
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