Original paper

Macrophage development and activation involve coordinated intron retention in key inflammatory regulators

Volume: 48, Issue: 12, Pages: 6513 - 6529
Published: May 25, 2020
Abstract
Monocytes and macrophages are essential components of the innate immune system. Herein, we report that intron retention (IR) plays an important role in the development and function of these cells. Using Illumina mRNA sequencing, Nanopore direct cDNA sequencing and proteomics analysis, we identify IR events that affect the expression of key genes/proteins involved in macrophage development and function. We demonstrate that decreased IR in...
Paper Details
Title
Macrophage development and activation involve coordinated intron retention in key inflammatory regulators
Published Date
May 25, 2020
Volume
48
Issue
12
Pages
6513 - 6529
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