Galectin‐8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts

Background and Objective During cyclosporine‐induced gingival overgrowth, the homeostatic balance of gingival connective tissue is disrupted leading to fibrosis. Galectins are glycan‐binding proteins that can modulate a variety of cellular processes including fibrosis in several organs. Here, we study the role of galectin‐8 (Gal‐8) in the response of gingival connective tissue cells to cyclosporine. Methods We used human gingival fibroblasts and...