Hormone Signaling Pathways in the Postnatal Mammary Gland

Published on Jan 1, 2020
· DOI :10.1007/978-3-030-44436-5_10
Fátima Liliana Monteiro4
Estimated H-index: 4
Inês Direito3
Estimated H-index: 3
(University of Aveiro),
Luisa A. Helguero26
Estimated H-index: 26
📖 Papers frequently viewed together
5 Authors (James DeRose, ..., Cathrin Brisken)
164 Citations
1 Author (송수진)
#1Inês DireitoH-Index: 3
#2Margarida Fardilha (University of Aveiro)H-Index: 18
Last. Luisa A. HelgueroH-Index: 26
view all 3 authors...
: Resistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in bo...
2 CitationsSource
#1Manoj Kumar Jena (NDRI: National Dairy Research Institute)H-Index: 11
#2Shalini Jaswal (NDRI: National Dairy Research Institute)H-Index: 3
Last. Ashok Kumar Mohanty (NDRI: National Dairy Research Institute)H-Index: 19
view all 4 authors...
Abstract The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway of lactation – involution – lactation, fine-tuning these molecular events through hormones, growth factors and other regulatory molecules. The developmental stages of the ...
18 CitationsSource
#1Anni Wärri (UTU: University of Turku)H-Index: 26
#2Katherine L. Cook (Wake Forest University)H-Index: 21
Last. Robert Clarke (GUMC: Georgetown University Medical Center)H-Index: 129
view all 9 authors...
The postnatal mammary gland undergoes repeated cycles of proliferation and cell death, most notably when the fully differentiated (lactating) gland dedifferentiates to a prelactation state. Accumulation of milk proteins in the secretory epithelium creates the stress signal that triggers this process (involution). How this stress is perceived, and the cellular processes that are subsequently activated, remain unclear. We now report that Unfolded Protein Response (UPR), autophagy, and apoptosis re...
19 CitationsSource
#1R. K. Singh (OSU: Ohio State University)H-Index: 9
#1Rajbir Singh (OSU: Ohio State University)H-Index: 21
Last. Mark R. Parthun (OSU: Ohio State University)H-Index: 29
view all 4 authors...
: Replication-dependent histones are expressed in a cell cycle regulated manner and supply the histones necessary to support DNA replication. In mammals, the replication-dependent histones are encoded by a family of genes that are located in several clusters. In humans, these include 16 genes for histone H2A, 22 genes for histone H2B, 14 genes for histone H3, 14 genes for histone H4 and 6 genes for histone H1. While the proteins encoded by these genes are highly similar, they are not identical. ...
19 CitationsSource
#1Christopher Dravis (Salk Institute for Biological Studies)H-Index: 15
#2Chi-Yeh Chung (Salk Institute for Biological Studies)H-Index: 10
Last. Geoffrey M. Wahl (Salk Institute for Biological Studies)H-Index: 77
view all 8 authors...
Summary Cell state reprogramming during tumor progression complicates accurate diagnosis, compromises therapeutic effectiveness, and fuels metastatic dissemination. We used chromatin accessibility assays and transcriptional profiling during mammary development as an agnostic approach to identify factors that mediate cancer cell state interconversions. We show that fetal and adult basal cells share epigenetic features consistent with multi-lineage differentiation potential. We find that DNA-bindi...
53 CitationsSource
#1Holly Holliday (UNSW: University of New South Wales)H-Index: 3
#2Laura A. Baker (UNSW: University of New South Wales)H-Index: 5
Last. Alexander Swarbrick (UNSW: University of New South Wales)H-Index: 32
view all 5 authors...
Differentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process, the majority of DNA needs to be packaged into inactive heterochromatin, allowing only a subset of regulatory elements to remain open and functionally required genes to be expressed. Epigenetic mechanisms such as DNA methylation, post-translational modifications to histone tails, and nucleosome positioning ...
9 CitationsSource
#1Caroline A. Lamb (Instituto de Biología y Medicina Experimental)H-Index: 11
#2Victoria T. Fabris (Instituto de Biología y Medicina Experimental)H-Index: 10
Last. Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
view all 5 authors...
Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Biologia y Medicina Experimental. Fundacion de Instituto de Biologia y Medicina Experimental. Instituto de Biologia y Medicina Experimental; Argentina
11 CitationsSource
#1Carolyn M. KlingeH-Index: 41
1 CitationsSource
#1Wooyoung Jeong (DU: Dankook University)H-Index: 17
#2Hyocheol Bae (KU: Korea University)H-Index: 8
Last. Gwonhwa Song (KU: Korea University)H-Index: 30
view all 6 authors...
: Fibroblast growth factor (FGF) signaling plays essential roles in tissue development and homeostasis. Accumulating evidence reveals that fibroblast growth factor 2 (FGF2) regulates ductal elongation, which requires cell proliferation and epithelial expansion in the mammary gland. However, the function and mechanisms by which FGF2 controls functionality of epithelial cells is less well defined. Here, we demonstrate the functional effects of FGF2 on bovine mammary epithelial (MAC-T) cells and th...
4 CitationsSource
#1Jerrica L. Breindel (Tufts University)H-Index: 3
#2Adam Skibinski (Tufts University)H-Index: 10
Last. Charlotte Kuperwasser (Tufts University)H-Index: 44
view all 10 authors...
Summary Organogenesis and tissue development occur through sequential stepwise processes leading to increased lineage restriction and loss of pluripotency. An exception to this appears in the adult human breast, where rare variant epithelial cells exhibit pluripotency and multilineage differentiation potential when removed from the signals of their native microenvironment. This phenomenon provides a unique opportunity to study mechanisms that lead to cellular reprogramming and lineage plasticity...
13 CitationsSource
Cited By0