Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice

Volume: 487, Pages: 53 - 62
Published: Sep 1, 2020
Abstract
Tumor-stromal interaction is implicated in tumor progression. Although CCR1 expression in myeloid cells could be associated with pro-tumor activity, it remains elusive whether disruption of CCR1-mediated myeloid cell accumulation can suppress tumor progression. Here, we investigated the role of CCR1 depletion in myeloid cells in two syngeneic colorectal cancer mouse models: MC38, a transplanted tumor model and CMT93, a liver metastasis model....
Paper Details
Title
Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice
Published Date
Sep 1, 2020
Volume
487
Pages
53 - 62
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