Cobalt-catalysed C–H methylation for late-stage drug diversification
Abstract
The magic methyl effect is well acknowledged in medicinal chemistry, but despite its significance, accessing such analogues via derivatization at a late stage remains a pivotal challenge. In an effort to mitigate this major limitation, we here present a strategy for the cobalt-catalysed late-stage C–H methylation of structurally complex drug molecules. Enabling broad applicability, the transformation relies on a boron-based methyl source and...
Paper Details
Title
Cobalt-catalysed C–H methylation for late-stage drug diversification
Published Date
May 29, 2020
Journal
Volume
12
Issue
6
Pages
511 - 519
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