A multi-center assessment to compare residual allergenicity of partial hydrolyzed whey proteins in a murine model for cow’s milk allergy – Comparison to the single parameter guinea pig model

This 4-center study is part of a project to validate a food allergy murine model for safety testing of hydrolyzed infant formulas. The aim of the current multi-center experiment was to evaluate the residual allergenicity of three partial hydrolyzed whey proteins (pWH) in a multiple-parameter cow’s milk allergy murine model and to compare to the classically used guinea pig model. Previous work showed differences in the magnitude of the allergic...