Nox4 Expression Is Not Required for OVX-Induced Osteoblast Senescence and Bone Loss in Mice.

Published on Jul 23, 2020
· DOI :10.1002/JBM4.10376
Jin-Ran Chen26
Estimated H-index: 26
(University of Arkansas for Medical Sciences),
Oxana P. Lazarenko18
Estimated H-index: 18
(University of Arkansas for Medical Sciences)
+ 4 AuthorsMartin J. J. Ronis48
Estimated H-index: 48
(LSU Health Sciences Center New Orleans)
Sources
Abstract
📖 Papers frequently viewed together
2020
6 Citations
References47
Newest
#1Kim B. Pedersen (Goethe University Frankfurt)H-Index: 1
#2Michelle L. OsbornH-Index: 2
Last. Martin J. J. Ronis (Goethe University Frankfurt)H-Index: 1
view all 8 authors...
Bone loss in response to alcohol intake has previously been hypothesized to be mediated by excessive production of reactive oxygen species (ROS) via NADPH oxidase (Nox) enzymes. Nox4 is one of several Nox enzymes expressed in bone. We investigated the role of Nox4 in the chondro-osteoblastic lineage of the long bones in mice during normal chow feeding and during chronic ethanol feeding for 90 days. We generated mice with a genotype (PrxCre +/- Nox4 fl/fl) allowing conditional knockout of Nox4 in...
3 CitationsSource
#1Jin-Ran Chen (University of Arkansas for Medical Sciences)H-Index: 26
#2Umesh D. Wankhade (University of Arkansas for Medical Sciences)H-Index: 12
Last. Oxana P. Lazarenko (University of Arkansas for Medical Sciences)H-Index: 18
view all 6 authors...
: Phenolic acids (PAs) are metabolites derived from polyphenolic compounds found in fruits and vegetables resulting from the actions of gut bacteria. Previously, we reported that the levels of seven individual PAs were found to be at least 10 times higher in the serum of rats fed a blueberry (BB)-containing diet compared to those fed a control diet. We have characterized the effects of one such BB-associated serum PA, 3-(3-hydroxyphenyl)-propionic acid (PPA), on senescence signaling and promotio...
2 CitationsSource
#1Gabriele Russow (Humboldt University of Berlin)H-Index: 1
#2Denise Jahn (Humboldt University of Berlin)H-Index: 1
Last. Johannes Keller (Humboldt University of Berlin)H-Index: 15
view all 6 authors...
Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expectancy in modern societies, the global implications of osteoporosis and impaired bone healing are substantial. Research in the last decades has revealed several molecular pathways t...
28 CitationsSource
#1Clemente F. Arias (Complutense University of Madrid)H-Index: 7
#2Miguel A. Herrero (Complutense University of Madrid)H-Index: 11
Last. José María Cuenca López (University of Oviedo)H-Index: 26
view all 5 authors...
The human skeleton undergoes constant remodeling throughout the lifetime. Processes occurring on microscopic and molecular scales degrade bone and replace it with new, fully functional tissue. Multiple bone remodeling events occur simultaneously, continuously and independently throughout the body, so that the entire skeleton is completely renewed about every ten years.Bone remodeling is performed by groups of cells called Bone Multicellular Units (BMU). BMUs consist of different cell types, some...
11 CitationsSource
Approximately 10 million men and women in the U.S. have osteoporosis,1 a metabolic bone disease characterized by low bone density and deterioration of bone architecture that increase the risk of fractures.2 Osteoporosis-related fractures can increase pain, disability, nursing home placement, total health care costs, and mortality.3 The diagnosis of osteoporosis is primarily determined by measuring bone mineral density (BMD) using noninvasive dual-energy x-ray absorptiometry. Osteoporosis medicat...
82 Citations
#1Domazetovic (UniFI: University of Florence)H-Index: 1
#2Gemma Marcucci (UniFI: University of Florence)H-Index: 13
Last. Maria Teresa Vincenzini (UniFI: University of Florence)H-Index: 19
view all 5 authors...
: ROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants. The natural antioxidants are: thiol compounds among which GSH is the most representative, and non-thiol compounds such as polyphenols, vitamins and also various enzymes. Many diseases have been linked to oxidative stress including bone diseases...
157 CitationsSource
#1Umesh D. Wankhade (University of Arkansas for Medical Sciences)H-Index: 12
#2Ying Zhong (University of Arkansas for Medical Sciences)H-Index: 12
Last. Kartik Shankar (University of Arkansas for Medical Sciences)H-Index: 43
view all 7 authors...
Objective Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis. However, the contributions of gestational and early life influences on development of NAFLD and NASH remain poorly appreciated. Methods Two independent studies were performed to examine whether maternal over-nutrition via exposure to high fat diet (HFD) leads to exacerbated hepatic responses to post-natal HFD and methionine choline deficient (MCD) diets in ...
67 CitationsSource
#1Jin-Ran ChenH-Index: 26
#2Oxana P. LazarenkoH-Index: 18
Last. Kartik ShankarH-Index: 43
view all 8 authors...
Nutritional status during intrauterine and early postnatal life impacts the risk of chronic diseases, presumably via epigenetic mechanisms. However, evidence on the impact of gestational events on regulation of embryonic bone cell fate is sparse. We investigated the effects of maternal obesity on fetal osteoblast development in both rodents and humans. Female rats were fed control or an obesogenic high-fat diet (HFD) for 12 weeks and mated with male rats fed control diets, and respective materna...
20 CitationsSource
#1Panagiotis Lepetsos (UoA: National and Kapodistrian University of Athens)H-Index: 9
#2Athanasios G. Papavassiliou (UoA: National and Kapodistrian University of Athens)H-Index: 57
Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of the population. Its multi-factorial etiology includes oxidative stress and the overproduction of reactive oxygen species, which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation along with synovial inflammation and dysfunction of the subchondral bone. As disease-modifying drugs for osteoarthritis are rare, targeting the complex...
236 CitationsSource
#1Jin-Ran Chen (University of Arkansas for Medical Sciences)H-Index: 26
#2Oxana P. Lazarenko (University of Arkansas for Medical Sciences)H-Index: 18
Last. Martin J. J. Ronis (University of Arkansas for Medical Sciences)H-Index: 48
view all 6 authors...
Abstract Bone remodeling is age-dependently regulated and changes dramatically during the course of development. Progressive accumulation of reactive oxygen species (ROS) has been suspected to be the leading cause of many inflammatory and degenerative diseases, as well as an important factor underlying many effects of aging. In contrast, how reduced ROS signaling regulates inflammation and remodeling in bone remains unknown. Here, we utilized a p47phox knock-out mouse model, in which an essentia...
20 CitationsSource
Cited By0
Newest