Phthalocyanine-DNA origami complexes with enhanced stability and optical properties.

Published on Jul 2, 2020in Chemical Communications5.996
· DOI :10.1039/D0CC01916J
Ahmed Shaukat3
Estimated H-index: 3
(Aalto University),
Eduardo Anaya-Plaza8
Estimated H-index: 8
(Aalto University)
+ 4 AuthorsMauri A. Kostiainen36
Estimated H-index: 36
(Aalto University)
Sources
Abstract
In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically-related media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.
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