Systemic delivery of C II TA siRNA reduces disease severity in collagen-induced arthritis

Volume: 32, Issue: 04, Pages: 302 - 308
Published: Apr 1, 2012
Abstract
Objective To examine the therapeutic effect of C Ⅱ TA inhibition in collagen-induced arthritis(CIA),using a delivery system tailored to target C ⅡTA gene by small interfering RNA (siRNA).Methods Mice with collagen-induced arthritis were injected intravenously with C Ⅱ TA siRNA.The clinical score was monitored for up to 4 weeks after treatment.The severity of inflammation of mouse joint was evaluated by histological examination.Real-time PCR was...
Paper Details
Title
Systemic delivery of C II TA siRNA reduces disease severity in collagen-induced arthritis
Published Date
Apr 1, 2012
Volume
32
Issue
04
Pages
302 - 308
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