Increased Physical Activity During Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice

It has been recognized that mechanical stresses associated with physical activity (PA) have beneficial effects on increasing bone mineral density (BMD) and improving bone quality in humans and animal models. On the other hand, in rodents, high fat diet (HFD) and obesity increase bone marrow adiposity leading to increased production of pro-inflammatory cytokines that activate RANKL-induced bone resorption. In the current study, we investigated...